26/6/2025–|Last update: 16:03 (Mecca time)
Gina researchers have identified its activation by tension to the destruction of the Beta Bankeri cells, which are the cells responsible for production Insulin Control of blood sugar, which leads to a defect in its function.
The discovery of this gene opens new horizons for early diagnosis and treatment Diabetics of the second typeThe researchers hope to pave the way for the development of new drugs targeting this disease.
And run the study Researchers from the University of Osaka Metropolitan in Japan, and its results were published in the Journal of Biology Chemhyry on May 21, and the Yurrick Alert website was written.
The lifestyle, especially the diet, plays a major role in the emergence of type 2 diabetes, and genes have an important role as well, but bad eating habits can significantly increase the risk of developing what is now called the “silent epidemic”.
“Type 2 diabetes occurs when the Beta -Benkerian beta cells, which secrete insulin to regulate the level of blood sugar, are damaged, due to the prolonged stress caused by bad eating habits, a condition known as oxidative stress,” says Nuke Harada, associate professor at the College of Graduate Studies for Agriculture at the University of Osaka Metropolitan and the main author of this study.
What weakens these cells?
To answer this question, the team resorted to a Jin study that responds to stress called “RED 2” (Redd2).
These types of genes are activated when cells are pressure, and these genes help cells in strategies adapting to stress, but this may come with counter -results at times.
“We noticed that the increase in the expression of this gene is damaging beta cells, which in turn leads to a decrease in insulin secretion and the emergence of diabetes,” says Harada.
The team found that the “RDD 2” activity increased dramatically when beta cells were subjected to high levels of glucose (blood sugar), fatty acids and “Streptozotocin”, which is a chemical that is usually used for diabetes model Her excessive RDD 2 to increase the death of cells and disrupt a major cellular growth path.
Other experiments on cells and laboratory mice that suffer from a “REDD 2” deficiency have shown that they have better control of blood sugar when following a diet rich in fat or exposure to chemicals that cause diabetes, and these mice also have more numbers of the healthy beta cells and produced more insulin.
The analysis of the data of the Human Pancreatic Islands supports the negative effects of “RED 2” on the Beta cells and its ability to secrete insulin.
“We found that inhibition of RED 2 expression protects beta cells from damage to the pressure of excessive eating, preventing the appearance of diabetes,” said Hararada.