I looked study A new tray in developments scored in the field of wound treatment, specifically focused on the sensitive bands of the environment surrounding the wounds of patients Diabetes.
The wounds associated with diabetes, such as Sugary footOne of the common complications associated with diabetes. Diabetic foot ulcers are an open sore or wound, and it affects about 15% of diabetics, and it usually appears at the bottom of the foot.
6% of people with foot ulcers are inserted into the hospital due to infection or other complications related to ulcers, according to the American Medical Association of Medicine. Nearly 14-24% of diabetics who have an ulceice in the foot need amputation.
The study was conducted by researchers from the People’s Hospital, the Hangzhou Faculty of Medicine and the main laboratory for the installation of biological organic materials in Zhejiang Province, College of Biotechnology and Biological Engineering, Zhejiang University of Technology in China, and published in the Journal of Engineering on May 13, and was written by Urik Alrt.
The researchers revealed that over the past 30 years, more than 3,000 patents and 300 scientific manuscripts have been published about biologically active bandages to treat diabetes wounds. These bandages were designed to interact with and adjust diabetics. These innovations have led to a model known as “responding to the exact environment with the organization when needed”, and aims to provide an accurate treatment that responds to dynamic changes within the wounds of diabetics.
How do wounds heal?
Diabetes wound healing is different from the normal wound healing process and is a complex process. The wounds pass through several stages before they heal, and these stages are: the stage of stopping the bleeding where the blood vessels are narrowed and the platelets collect to stop the bleeding, and diabetics often suffer from abnormal accumulation of platelets and the formation of the fibrin network (the main structural component of the blood clot that proves the platelets that form when the blood vessels are injured).
The wounds pass through the healing journey in a second stage, which is the inflammatory stage, in which a flow of a variety of inflammatory cells occurs, and the diabetics are infected with the inflammatory stage due to the poor immune cell function, the imbalance of inflammatory media (small molecules and important proteins to amplify and end different types of inflammatory responses), and other factors such as excessive production of interactive oxygen (reactive oxygen Specials that cause oxidative stress. It is difficult to treat the ongoing infection that the patient suffers from.
The inflammatory stage follows the breeding stage, and at this stage, new blood vessels are formed, and diabetics at this stage suffer from the weakness of the normal function of some cells such as keratin cells and fibroids. A lack of oxygen is weakened cell functions and vascular formation.
As for the last stage, it is the stage of rebuilding, which is the stage in which the wound reaches the maximum strength of strength, and at this stage the fibrous cells secrete the muscular cells Collagen (A type of protein that is widely scattered in the body) of the third type and then collagen of the first type, after which the reorganization of collagen increases the strength of the fiber in the wound.
Although the deposition of collagen is crucial to wound healing, unorganized collagen deposition can also lead to complications. The quality of collagen deposition in diabetics is poor, making the wound vulnerable to relapse.
The accurate environment of deep wounds is characterized by high levels Glucose (Blood sugar), the high glucose is enhanced by the accumulation of “Glycation End-PRODUCTS”, which not only prolongs the inflammatory response, but also affects the migration and multiplication of the main healing cells.
And the products of the endocrinology are proteins or fats that plunge after exposure to sugars. These products are spread in the blood vessels of diabetics, and contribute to the development arteriosclerosis. The presence of these products and their accumulation in different types of cells affects the structure and function inside and outside the cells. These products also contribute to a variety of complications. The turbulent factors – including the excessive accumulation of the products of the endocrinology and interactive oxygen – hinder the natural wound healing process.
Biologically active bands
To face these challenges, the researchers have developed biological dressing up to the accurate environment with demand regulation. These bandages can be classified as bandits that use negative and other active regulatory strategies on request.
The negative regulation strategy includes a sensor of glucose (blood sugar), the regulation of an acidity sensor (modification of the release of the drug based on pH changes), anti -oxidant regulation, anti -inflammatory, and anti -infection (removal of interactive oxygen types, bacterial inhibition, reducing inflammation), regulating sensitive to turbulent factors such as targeting the outcomes of the ends of the ends, and regulation Sensitive to temperature and humidity (responding to temperature and humidity changes).
Active regulation strategies on request include organizing ultrasound sensor (stimulating the release of the drug with ultrasound), organizing a magnetic sensor (using magnetic fields of treatment), and regulating a light sensor (using optical stimulus and optical heat).
However, the medical application of biologically active dressings is still facing challenges. The biological safety of innovative materials must be analyzed accurately, and must be compatible with organizational standards. Various bandages may require different approval paths from the American Food and Drug Administration, according to their properties.
Future research should focus on smart response mechanisms, building connection systems, biological compatibility, improving mechanical properties, mergers, and multi -function design, in order to improve the effectiveness of these bandages in treating diabetic wounds.